반응 #931202

반응 방정식

1,4-Dioxa-spiro[4.5]decane-8-carbonitrile

hydrochloric acid

→

oil

수율 50.8%

4-Oxo-cyclohexanecarbonitrile

수율 50.8%

용매

ethyl acetate

tetrahydrofuran

반응 조건

후처리

1. 1
   세척washed with water and brine
2. 2
   건조dried over MgSO4
3. 3
   여과filtered
4. 4
   농축concentrated to an oil which
5. 5
   기타was purified via flash chromatography on silica using 10% ethyl acetate/hexane as eluent

실험 절차

A solution of 1,4-Dioxa-spiro[4.5]decane-8-carbonitrile (2.0 grams, 12.8 mmole) and 2 N hydrochloric acid (21.0 grams, 42.0 mmole) in tetrahydrofuran (30 ml) at room temperature was stirred over night. The mixture was diluted with ethyl acetate, washed with water and brine, dried over MgSO4, filtered, and concentrated to an oil which was purified via flash chromatography on silica using 10% ethyl acetate/hexane as eluent to give an oil (0.800 g). MW 123.15.

출처