반응 #92974

반응 방정식

1,4-dichloro-2-butanol

water

2-methoxyphenol

sodium hydroxide

→

4-Chloro-1-(2-methoxyphenoxy)-2-butanol

용매

isopropanol

반응 조건

후처리

1. 1
   온도The mixture was refluxed gently overnight
2. 2
   추출The reaction mixture was extracted with 1 liter of isopropyl ether
3. 3
   건조dried over sodium sulfate
4. 4
   workup.DISTILLATIONdistilled under reduced pressure
5. 5
   workup.DISTILLATIONThe distillate which was collected at 136°-138° C./0.015 mm

실험 절차

To a mixture of 2 moles (248.26 g.) of 2-methoxyphenol, 4 moles (160 g.) of sodium hydroxide, 250 ml. of water and 1 liter of isopropanol was added with stirring 2.2 moles (314.64 g.) of 1,4-dichloro-2-butanol. The mixture was refluxed gently overnight. The reaction mixture was extracted with 1 liter of isopropyl ether, dried over sodium sulfate and distilled under reduced pressure. The distillate which was collected at 136°-138° C./0.015 mm. (396.8 g.) solidified to a white crystalline solid which melted at 48°-50° C.

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