반응 #92971

반응 방정식

1,4-dichloro-2-butanol

4-phenylphenol

sodium hydroxide

→

4-Chloro-(4-biphenylyloxy)-2-butanol

용매

water

반응 조건

후처리

1. 1
   온도The resulting mixture was heated at 68° C. in a steam bath for 6 hr
2. 2
   온도, cooled
3. 3
   추출extracted with 300 ml
4. 4
   추출The chloroform extract
5. 5
   세척was washed with water to neutrality
6. 6
   건조dried over sodium sulfate
7. 7
   농축concentrated to dryness
8. 8
   기타The solid residue was recrystallized with isopropanol
9. 9
   기타yielded 180 g

실험 절차

To a solution of 1 mole (158 g.) of 4-phenylphenol 100 g. of sodium hydroxide and 500 ml. of water was added 1 mole (143.02 g.) of 1,4-dichloro-2-butanol with stirring at 40° C. The resulting mixture was heated at 68° C. in a steam bath for 6 hr., cooled and extracted with 300 ml. of chloroform. The chloroform extract was washed with water to neutrality, dried over sodium sulfate and concentrated to dryness. The solid residue was recrystallized with isopropanol and yielded 180 g. of a white crystalline solid which melted at 123°-124° C.

출처