반응 #92956

반응 방정식

ammonium hydroxide

N-(3-pyridyl)-indole

glutaric acid monoethyl ester chloride

→

3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole

용매

methylene chloride

methylene chloride

반응 조건

후처리

1. 1
   온도The reaction mixture is cooled to 10°-15°
2. 2
   기타The organic layer is separated
3. 3
   세척washed with water
4. 4
   건조dried over sodium sulfate

실험 절차

To a mixture of 10.0 g of N-(3-pyridyl)-indole (J. Chem. Soc. (C), 85, 1970) and 13.8 g of glutaric acid monoethyl ester chloride in 90 ml of methylene chloride is added dropwise over a period of 3 hours a solution of 20.1 g of stannic chloride in 60 ml of methylene chloride. The reaction mixture is stirred at room temperative overnight. The reaction mixture is cooled to 10°-15° and 150 ml of 14% aqueous ammonium hydroxide is added. The organic layer is separated, washed with water and dried over sodium sulfate to yield 3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole, melting at 95°-97°.

출처