반응 #929

반응 방정식

2,6-dinitrobenzonitrile

thiophenol

K2CO3

Pyridine

→

2-nitro-6-(phenylthio)benzonitrile

수율 89.0%

용매

H2O

DMF

반응 조건

후처리

1. 1
   여과The yellow precipitate was collected by filtration
2. 2
   세척washed with 1N NaOH, water
3. 3
   기타dried

실험 절차

An ice water bath-cooled mixture of 2.0 g (0.01 mol) of 2,6-dinitrobenzonitrile (Lancaster Synthesis, Inc., Windham, N.H. 03087), 1.06 ml (0.01 mol) of thiophenol, and 1.44 g (0.01 mol) of anhydrous K2CO3 in 50 mL of DMF was stirred for 0.5 h. Pyridine was added to the reaction mixture until it became basic, and was followed by the addition of approximately 100 mL of H2O. The yellow precipitate was collected by filtration, washed with 1N NaOH, water and dried to give 1.94 g (89%) of 2-nitro-6-(phenylthio)benzonitrile as a yellow solid: mp 106°-107° C.

출처