반응 #928140

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DL-malic acid

2-methyl-1-butanol

→

Di-(2-methylbutyl)-DL-malate

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후처리

1. 1
   기타Di(2-methylbutyl)-DL-malate was prepared
2. 2
   온도heated to reflux
3. 3
   기타At 108° C.
4. 4
   기타to collect in the Dean-Stark trap
5. 5
   기타to collect in the Dean-Stark trap
6. 6
   workup.ADDITIONthe product was diluted with diethyl ether
7. 7
   여과collected via filtration over a short bed of silica
8. 8
   세척washed 4 times with saturated sodium bicarbonate
9. 9
   건조once with water and dried over magnesium sulfate
10. 10
    기타The diethyl ether was removed via rotary evaporation

실험 절차

Di(2-methylbutyl)-DL-malate was prepared using a procedure similar to that in Example 4. To the reaction flask, DL-malic acid (100.56 g), 2-methyl-1-butanol (325 mL) and Amberlyst® 15 ion exchange resin (15.1 g) were added. The mixture was placed under nitrogen and heated to reflux. At 108° C., two phases started to collect in the Dean-Stark trap. After 1.5 hr, the reaction temperature was increased to 115° C. for 20 minutes and 120° C. for 20 minutes. Once water ceased to collect in the Dean-Stark trap, the product was diluted with diethyl ether, collected via filtration over a short bed of silica, washed 4 times with saturated sodium bicarbonate, once with water and dried over magnesium sulfate. The diethyl ether was removed via rotary evaporation. Di-(2-methylbutyl)-DL-malate was obtained as a low viscosity, clear, very light yellow liquid with no detectable odor (139.8 g, 68% yield) after removing residual 2-methyl-1-butanol via vacuum distillation.

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