반응 #92805

반응 방정식

p-toluenesulfonic acid monohydrate

norbornane-2-methanol

glutamic acid

→

γ-benzyl-L-glutamic acid γ-2-norbornylmethyl-L-glutamic acid

용매

1,2-dichloroethane

반응 조건

실험 절차

By a method similar to that of Synthetic Example 4, poly-γ-benzyl-L-glutamic acid was obtained and dissolved in 1,2-dichloroethane. Thereto were added an equivalent amount of norbornane-2-methanol (manufactured by Tokyo Chemical Industry Co., Ltd.) relative to the glutamic acid unit of poly-γ-benzyl-L-glutamic acid and a catalytic amount of p-toluenesulfonic acid monohydrate, and the mixture was stirred at 65° C. for 4 days to give a γ-benzyl-L-glutamic acid/γ-2-norbornylmethyl-L-glutamic acid copolymer. The weight average molecular weight, Mw, of the obtained copolymer was measured by Measurement Method 1 described below. In addition, the composition of the polymer after transesterification reaction was measured by Measurement Method 2 described below.

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