반응 #927284

ord-89e1ac7467b941d290e4b0902d15b368

반응 방정식

C=Cc1ccc2c3c1OC1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
4,5-epoxy-17-methyl-3-vinylmorphinan-6-one
→
CCc1ccc2c3c1OC1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
title product
수율 63.8%
CCc1ccc2c3c1OC1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
4,5-Epoxy-3-ethyl-17-methylmorphinan-6-one
수율 63.8%

반응물

C=Cc1ccc2c3c1OC1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
4,5-epoxy-17-methyl-3-vinylmorphinan-6-one

시약

[Pd]
Pd on charcoal

용매

CCO
EtOH

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    여과The catalyst was filtered off
  2. 2
    기타the solvent was removed in vacuo

실험 절차

1.2 g (4.06 mmol) of 4,5-epoxy-17-methyl-3-vinylmorphinan-6-one were dissolved in 150 ml of absolute EtOH. 1 g of 10% Pd on charcoal was added and the reaction mixture was hydrogenated in a Parr apparatus at 35 psi and at room temperature for 8 h. The catalyst was filtered off and the solvent was removed in vacuo, yielding 0.77 g of the title product.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06365594B1uspto-grants-2002_04