반응 #927236

반응 방정식

7-octynyl-p-toluenesulfonate

sodium iodide

→

8-iodo-1-octyne

수율 94.2%

용매

acetone

반응 조건

후처리

1. 1
   기타to react for four hours
2. 2
   온도under reflux
3. 3
   온도After cooling
4. 4
   기타the precipitates were removed by filtration
5. 5
   농축the filtrate was concentrated
6. 6
   기타The resulting residue was purified by silica gel column chromatography (eluent; hexane)

실험 절차

A mixture of 7-octynyl-p-toluenesulfonate (18.3 g, 65.2 mmol), sodium iodide (9.77 g, 65.2 mmol) and acetone (91 ml) was allowed to react for four hours under reflux. After cooling, the precipitates were removed by filtration, and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (eluent; hexane) to afford 14.5 g of 8-iodo-1-octyne (yield; 94.2%).

출처