반응 #927

반응 방정식

2-Aminonicotinaldehyde

2-acetylthiazole

KOH

→

desired product

수율 46.5%

2-(2-Thiazolyl)-1,8-naphthyridine

수율 46.5%

용매

MeOH

반응 조건

후처리

1. 1
   workup.ADDITIONthe mixture is poured onto water
2. 2
   여과The solid which is deposited is filtered off with suction
3. 3
   세척washed
4. 4
   기타dried

실험 절차

2-Aminonicotinaldehyde (1.5 g, 12.3 mmol) and 2-acetylthiazole (1.64 g, 12.9 mmol) are dissolved in 12 ml of MeOH and the mixture is treated with 1.5 ml of 40% KOH. After 3 h, the reaction is complete and the mixture is poured onto water. The solid which is deposited is filtered off with suction, washed and dried. 1.22 g (yield 46%) of the desired product are obtained. M.p. 160°-165° C.

출처