반응 #92691

반응 방정식

ethyl 1-{(2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl}piperidine-4-carboxylate

trifluoroacetic acid

→

ethyl 1-[(2R)-2-amino-2-phenylethyl]piperidine-4-carboxylate

수율 102.2%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The solvent was evaporated under reduced pressure
2. 2
   workup.ADDITIONa saturated aqueous sodium carbonate solution and a chloroform-methanol mixed solution were added
3. 3
   기타a layer separation operation
4. 4
   건조After drying over anhydrous magnesium sulfate
5. 5
   기타the solvent was evaporated under reduced pressure

실험 절차

To a solution of 160 mg of ethyl 1-{(2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl}piperidine-4-carboxylate in 1.5 mL of dichloromethane was added 0.7 mL of trifluoroacetic acid, followed by stirring for 1 hour. The solvent was evaporated under reduced pressure, and a saturated aqueous sodium carbonate solution and a chloroform-methanol mixed solution were added thereto in this order to carry out a layer separation operation. After drying over anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure to obtain 120 mg of ethyl 1-[(2R)-2-amino-2-phenylethyl]piperidine-4-carboxylate.

출처