반응 #92690

반응 방정식

ethyl acetate

8-(cyclohexylmethoxy)-N-(2,2-dimethoxyethyl)-2-methylimidazolo[1,2-a]pyridine-3-carboxamide

hydrochloric acid

→

8-(cyclohexylmethoxy)-2-methyl-N-(2-oxoethyl)imidazolo[1,2-a]pyridine-3-carboxamide

수율 94.0%

용매

brine

dioxane

반응 조건

후처리

1. 1
   기타a layer separation operation
2. 2
   workup.ADDITIONTo the obtained aqueous layer was added a 1 M aqueous sodium hydroxide solution
3. 3
   여과the resulting solid was collected by filtration
4. 4
   기타dried

실험 절차

To a solution of 200 mg of 8-(cyclohexylmethoxy)-N-(2,2-dimethoxyethyl)-2-methylimidazolo[1,2-a]pyridine-3-carboxamide in 2 mL of dioxane was added 6 M hydrochloric acid, followed by stirring for 7 hours. To the reaction mixture were added saturated brine and ethyl acetate to carry out a layer separation operation. To the obtained aqueous layer was added a 1 M aqueous sodium hydroxide solution, and the resulting solid was collected by filtration and dried to obtain 165 mg of 8-(cyclohexylmethoxy)-2-methyl-N-(2-oxoethyl)imidazolo[1,2-a]pyridine-3-carboxamide.

출처