반응 #92687

반응 방정식

sodium hydrogen carbonate

bromoacetone

methyl 6-amino-5-[(2-fluorobenzyl)oxy]nicotinate

bromoacetone

→

methyl 8-[(2-fluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-6-carboxylate

용매

ethanol

반응 조건

후처리

1. 1
   workup.STIRRINGby stirring at 80° C. for 4 hours
2. 2
   기타the solvent was evaporated under reduced pressure
3. 3
   추출by extracting with ethyl acetate
4. 4
   세척washing with saturated brine
5. 5
   건조After drying over anhydrous magnesium sulfate
6. 6
   여과filtering
7. 7
   기타the solvent was evaporated under reduced pressure
8. 8
   기타The obtained residue was purified by silica gel column chromatography

실험 절차

To a suspension of 2.15 g of methyl 6-amino-5-[(2-fluorobenzyl)oxy]nicotinate in 43 ml of ethanol was added 1.09 ml of bromoacetone, followed by stirring at 80° C. for 4 hours. To the reaction mixture was added 1.09 ml of bromoacetone, followed by stirring at 80° C. for 4 hours. To the reaction mixture was added a saturated aqueous sodium hydrogen carbonate solution, and the solvent was evaporated under reduced pressure, followed by extracting with ethyl acetate and washing with saturated brine. After drying over anhydrous magnesium sulfate and then filtering, the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 1.39 g of methyl 8-[(2-fluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-6-carboxylate.

출처