반응 #92679

반응 방정식

ethyl 8-[(2-fluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylate

THF

sodium hydroxide

→

8-[(2-fluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid

수율 100.7%

용매

ethanol

반응 조건

후처리

1. 1
   기타The solvent was evaporated under reduced pressure, and water and 1 M hydrochloric acid
2. 2
   workup.ADDITIONwere added
3. 3
   여과The insoluble material was collected by filtration
4. 4
   기타dried

실험 절차

To 2.16 g of ethyl 8-[(2-fluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylate were added 20 ml of THF, 40 ml of ethanol, and 20 ml of a 1 M aqueous sodium hydroxide solution, followed by stirring for 4 days. The solvent was evaporated under reduced pressure, and water and 1 M hydrochloric acid were added thereto. The insoluble material was collected by filtration and dried to obtain 1.99 g of 8-[(2-fluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid.

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