반응 #92675

반응 방정식

5-methyl-2-nitropyridin-3-ol

(bromomethyl)cyclohexane

potassium carbonate

water

→

3-(cyclohexylmethoxy)-5-methyl-2-nitropyridine

용매

DMF

hexane ethyl acetate

반응 조건

후처리

1. 1
   기타After leaving
2. 2
   온도to be cooled at room temperature, to the reaction mixture
3. 3
   기타a layer separation operation
4. 4
   세척The organic layer was washed with water and saturated brine
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   기타the solvent was evaporated under reduced pressure

실험 절차

A suspension of 1 g of 5-methyl-2-nitropyridin-3-ol, 1.35 ml of (bromomethyl)cyclohexane, and 1.79 g of potassium carbonate in 10 ml of DMF was stirred at 78° C. for 12 hours. After leaving to be cooled at room temperature, to the reaction mixture were added water and hexane/ethyl acetate to carry out a layer separation operation. The organic layer was washed with water and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain 1.8 g of 3-(cyclohexylmethoxy)-5-methyl-2-nitropyridine.

출처