반응 #926148

반응 방정식

hydrochloride

5,6-dimethoxy-1-methyl benzimidazole

N-(2-furoyl) piperazine

2-methoxyethanol

HCl

→

1-(5,6-Dimethoxy-1-methyl-2-benzimidazolyl)-4-(2-furoyl) piperazine hydrochloride

용매

isopropyl alcohol

isopropyl alcohol

반응 조건

실험 절차

3.50 g. 2-chloro. 5,6-dimethoxy-1-methyl benzimidazole [(J. Org. Chem. USSR 1 1466), (1965)] 7.00 g N-(2-furoyl) piperazine, and 25 ml 2-methoxyethanol were reacted as described in Example I. The product was converted to its hydrochloride by dissolving in isopropyl alcohol and acidifying with a solution of HCl gas in isopropyl alcohol. Yield: 3.99 g product, mp 212°-215° C decomp.

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