반응 #9246

반응 방정식

1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea

triethylamine

2-fluorophenyl isocyanate

→

desired compound

수율 26.0%

1-(6-(3-(2-Fluorophenyl)aminocarbonylamino-propanoyl)-2-benzothiazolyl)-3-ethylurea

수율 26.0%

용매

DMF

반응 조건

후처리

1. 1
   기타Similar to the synthesis of Example 249
2. 2
   기타was reacted

실험 절차

Similar to the synthesis of Example 249, a mixture of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea, triethylamine and 2-fluorophenyl isocyanate in DMF was reacted to give the desired compound 0.022 g (26%). LC/MS 430.01 (M+1); LC retention time 2.89 min.

출처