반응 #9236

반응 방정식

phenyl isocyanate

1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea

triethylamine

→

desired compound

수율 22.0%

1(6-(3-Phenylaminocarbonylamino-propanoyl)-2-benzothiazolyl)-3-ethylurea

수율 22.0%

용매

DMF

반응 조건

후처리

1. 1
   workup.STIRRINGIt was stirred for about 2.5 hours
2. 2
   기타quenched with MeOH
3. 3
   여과filtered
4. 4
   농축concentrated
5. 5
   기타purified by HPLC

실험 절차

A solution of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea (0.033 g, 0.10 mmol) in 1 mL anhydrous DMF was treated with triethylamine (0.028 mL, 0.20 mmol, 2.0 eq) at room temperature. It was stirred for about 5 min, followed by the addition of phenyl isocyanate (0.013 mL, 0.12 mmol, 1.2 eq). It was stirred for about 2.5 hours, quenched with MeOH, filtered, concentrated, and purified by HPLC to give the desired compound 0.009 g (22%). LC/MS 412.2 (M+1); LC retention time 2.80 min.

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