반응 #92350

반응 방정식

1-ethylpiperazine

K2CO3

ethyl 2-bromoacetate

→

Ethyl 2-(4-ethylpiperazin-1-yl)acetate

수율 76.4%

용매

DMF

반응 조건

후처리

1. 1
   기타The mixture was quenched
2. 2
   추출extracted as in Intermediate Example 5(a)
3. 3
   workup.DISTILLATIONThe solvent was distilled off
4. 4
   기타to afford the product in 76.4% yield (1.3 g)

실험 절차

To a solution of 1-ethylpiperazine (1 g, 8.771 mmol, 1.0 eq) in DMF were added K2CO3 (3 g, 21.927 mmol, 2.5 eq.) and ethyl 2-bromoacetate (2.19 g, 13.156 mmol, 1.5 eq.). The mixture was stirred at RT for 16 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 76.4% yield (1.3 g).

출처