반응 #92334

반응 방정식

1-Methylpiperidin-4-ol

Et3N

methanesulfonyl chloride

→

crude product

수율 99.9%

1-Methylpiperidin-4-yl methanesulfonate

수율 99.9%

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타quenched
2. 2
   추출extracted as in Intermediate Example 5(a)
3. 3
   workup.DISTILLATIONThe solvent was distilled off

실험 절차

1-Methylpiperidin-4-ol (4 g, 34.7 mmol) was dissolved in CH2Cl2 (70 ml) at 0° C. followed by the addition of Et3N (10 ml, 69.4 mmol, 2 eq.) and methanesulfonyl chloride (2.7 ml, 34.7 mmol, 1 eq.). The mixture was stirred at RT for 3 h and quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the crude product (6.7 g).

출처