반응 #9229

반응 방정식

1-(6-phenylacetylenyl-2-benzothiazolyl)-3-ethylurea

→

desired compound

수율 41.0%

1-(6-(2(Z)-Phenylvinyl)-2-benzothiazolyl)-3-ethylurea

수율 41.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타was purged with nitrogen gas
2. 2
   기타by bubbling of hydrogen gas
3. 3
   여과filtered
4. 4
   농축concentrated
5. 5
   기타purified by preparative TLC

실험 절차

A suspension of 1-(6-phenylacetylenyl-2-benzothiazolyl)-3-ethylurea (0.032 g, 83% purity by weight, 0.083 mmol) and Lindlar catalyst (0.030 g, 5% weight purity, 0.012 mmol, 0.15 eq) in 2 mL ethanol was purged with nitrogen gas, followed by bubbling of hydrogen gas. It was stirred under hydrogen atmosphere for about 36 hours. The mixture was taken up in 10 mL MeOH, filtered, concentrated, and purified by preparative TLC to give 0.011 g (41%) of the desired compound. LC/MS 324 (M+1); LC retention time 2.84 min.

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