반응 #9228

반응 방정식

1-(6-phenylacetylenyl-2-benzothiazolyl)-3-ethylurea

→

desired compound

수율 76.0%

1-(6-(2-Phenylethyl)-2-benzothiazolyl)-3-ethylurea

수율 76.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타was purged with nitrogen gas
2. 2
   기타by bubbling of hydrogen gas
3. 3
   여과filtered
4. 4
   농축concentrated
5. 5
   기타dried under vacuum

실험 절차

A suspension of 1-(6-phenylacetylenyl-2-benzothiazolyl)-3-ethylurea (0.048 g, 0.15 mmol) and 10% palladium on carbon (0.016 g, 10% weight purity, 0.015 mmol, 0.10 eq) in 2 mL ethanol was purged with nitrogen gas, followed by bubbling of hydrogen gas. It was stirred under hydrogen atmosphere for about 16 hours. The mixture was taken up in 8 mL MeOH, filtered, concentrated, and dried under vacuum to give 0.037 g (76%) of the desired compound. LC/MS 326.3 (M+1); LC retention time 2.84 min.

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