반응 #92202

반응 방정식

ethyl 3-(4-chlorobenzyl)-4-(3-chlorophenyl)-2-cyano-4-oxobutanoate

→

ethyl 2-amino-4-(4-chlorobenzyl)-5-(3-chlorophenyl)furan-3-carboxylate

수율 72.0%

용매

TFA

반응 조건

후처리

1. 1
   농축concentrated to a residue which
2. 2
   workup.ADDITIONwas diluted with EA (40 mL) and water (8 mL)
3. 3
   건조The organic layer was dried over Na2SO4
4. 4
   농축concentrated to a residue which
5. 5
   기타was purified by chromatography
6. 6
   세척eluted with PE/EA (5:1)

실험 절차

A solution of ethyl 3-(4-chlorobenzyl)-4-(3-chlorophenyl)-2-cyano-4-oxobutanoate (1.945 g, 5 mmol) in TFA (20 mL) was stirred at 100° C. for 3 h. The reaction was cooled to RT and concentrated to a residue which was diluted with EA (40 mL) and water (8 mL). The organic layer was dried over Na2SO4 and concentrated to a residue which was purified by chromatography eluted with PE/EA (5:1) to give ethyl 2-amino-4-(4-chlorobenzyl)-5-(3-chlorophenyl)furan-3-carboxylate (1.4 g, 72% yield) as a white solid. LCMS: MH+ 390 and TR=2.503 min.

출처