반응 #92201

반응 방정식

K2CO3

2-bromo-1-(3-chlorophenyl)-3-(4-chlorophenyl)propan-1-one

ethyl 2-cyanoacetate

→

ethyl 3-(4-chlorobenzyl)-4-(3-chlorophenyl)-2-cyano-4-oxobutanoate

수율 77.0%

용매

EA

water

DMF

반응 조건

후처리

1. 1
   세척The organic layer was washed with brine (3 mL)
2. 2
   건조dried over Na2SO4
3. 3
   농축concentrated

실험 절차

To a solution of 2-bromo-1-(3-chlorophenyl)-3-(4-chlorophenyl)propan-1-one (358 mg, 1 mmol) in DMF (3 mL) was added ethyl 2-cyanoacetate (226 mg, 2 mmol), followed by K2CO3 (276 mg, 2 mmol). The reaction was stirred at RT for 2 h then diluted with EA (10 mL) and water (3 mL). The organic layer was washed with brine (3 mL), dried over Na2SO4 and concentrated to give ethyl 3-(4-chlorobenzyl)-4-(3-chlorophenyl)-2-cyano-4-oxobutanoate (300 mg, 77% yield) as a yellow solid. LCMS: MH+ 390 and TR=2.334 min. Used without further purification.

출처