반응 #92199

반응 방정식

1-(3-chlorophenyl)-3-(4-chlorophenyl)prop-2-en-1-one

NH4Cl

→

1-(3-chlorophenyl)-3-(4-chlorophenyl)propan-1-one

수율 83.0%

용매

water

MeOH

반응 조건

후처리

1. 1
   온도The reaction was refluxed for 4 h
2. 2
   여과then filtered
3. 3
   농축The filtrate was concentrated to a residue which
4. 4
   기타was purified by chromatography PE/EA (5:1)

실험 절차

1-(3-chlorophenyl)-3-(4-chlorophenyl)prop-2-en-1-one (1.38 g, 5 mmol), Zn dust (1.95 g, 30 mmol), NH4Cl (2.67 g, 50 mmol) were combined in MeOH (10 mL) and water (5 mL). The reaction was refluxed for 4 h, cooled to RT then filtered. The filtrate was concentrated to a residue which was purified by chromatography PE/EA (5:1) to give 1-(3-chlorophenyl)-3-(4-chlorophenyl)propan-1-one (1.15 g, 83% yield) as a brown solid. MH+ 279 and TR=2.025 min.

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