반응 #92198

반응 방정식

1-(3-chlorophenyl)ethanone

4-chlorobenzaldehyde

KOH

→

1-(3-chlorophenyl)-3-(4-chlorophenyl)prop-2-en-1-one

수율 83.0%

용매

EtOH

반응 조건

후처리

1. 1
   여과then filtered the insoluble white solid
2. 2
   기타The solid was dried
3. 3
   세척washed with PE/EA (5:1, 10 mL)

실험 절차

To a solution of 1-(3-chlorophenyl)ethanone (1.54 g, 10 mmol), 4-chlorobenzaldehyde (1.4 g, 10 mmol) in EtOH (25 mL) was added aq. KOH (50% wt, 10 mmol, 0.56 mL). The reaction was stirred at RT for 2 h then filtered the insoluble white solid. The solid was dried and washed with PE/EA (5:1, 10 mL) to give 1-(3-chlorophenyl)-3-(4-chlorophenyl)prop-2-en-1-one (2.3 g, 83% yield) as a white solid. LCMS: MH+ 277 and TR=2.050 min. Used without further purification.

출처