반응 #9213

반응 방정식

1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea

(CF3SO2)2O

→

1-(6-Bromo-7-trifluoromethanesulfonyl-2-benzthiazolyl)-3-ethyl-urea

용매

pyridine

반응 조건

후처리

1. 1
   기타The solvent was then evaporated
2. 2
   기타The crude material was purified by LC/MS
3. 3
   기타to give 23 mg (32%) pure 14

실험 절차

To a solution of 1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea (50 mg, 0.158 mmol) in pyridine (1 mL) were added 3 portions of (CF3SO2)2O (29 μL, 0.174 mmol) about 45 minutes apart. The reaction mixture was stirred for about 3 hours at about 35° C. The solvent was then evaporated. The crude material was purified by LC/MS to give 23 mg (32%) pure 14. 1H NMR (DMSO) δ 1.09 (t, 3H, J=8 Hz CH3), 3.19 (m, 2H, CH2), 6.79 (br s, 1H, NH), 7.67 (d, 1H, J=12 Hz, ArH), 7.80 (d, 1H, J=8 Hz, ArH), 11.20 (br s, 1H, NH). HPLC retention time 3.58 minutes.

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