반응 #92105

반응 방정식

isoquinolin-5-amine

DIEA

isocyanatocyclopentane

→

1-Cyclopentyl-3-(isoquinolin-5-yl)urea

용매

DCM

반응 조건

후처리

1. 1
   기타the reaction was quenched with H2O (15 mL)
2. 2
   추출extracted with EtOAc (3×30 mL)
3. 3
   세척The combined organic layers were washed with brine (10 mL)
4. 4
   건조dried (MgSO4)
5. 5
   기타The impure yellow solid was collected

실험 절차

To isoquinolin-5-amine (0.23 g, 1.595 mmol) in DCM (5 mL) was added DIEA (0.557 mL, 3.19 mmol) and isocyanatocyclopentane (0.180 mL, 1.595 mmol). After 24 h, the reaction was quenched with H2O (15 mL) and extracted with EtOAc (3×30 mL). The combined organic layers were washed with brine (10 mL) and dried (MgSO4). The impure yellow solid was collected and was carried onto the next step. MS (ESI) m/z: 256 (M+H)+.

출처