반응 #9210

반응 방정식

1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea

1-(6-Bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea

potassium carbonate

2-bromopropane

→

desired compound 11

수율 81.0%

1-(6-Bromo-7-isopropoxy-2-benzothiazolyl)-3-ethyl-urea

수율 81.0%

용매

DMF

반응 조건

후처리

1. 1
   기타was reacted

실험 절차

A mixture of 1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea 6, potassium carbonate and 2-bromopropane in DMF was reacted to give 0.046 g (81%) of the desired compound 11. 1H NMR (DMSO) δ 10.83 (br s, 1H, NH), 7.55 (d, 1H, J=8.5 Hz, ArH), 7.31 (d, 1H, J=8.6 Hz, ArH), 6.71 (br s, 1H, NH), 4.69 (hept, 1H, J=6.0 Hz, CH), 3.18 (m, 2H, CH2), 1.32 (d, 6H, J=6.1 Hz, CH3), 1.09 (t, 3H, J=7.2 Hz, CH3); LC/MS 358 (MH+); RP-HPLC RT 3.42 minutes.

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