반응 #92099

반응 방정식

Intermediate 5C

(E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate

NaOH

→

Intermediate 5

수율 42.1%

(E)-3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylic acid

수율 42.1%

용매

MeOH

THF

반응 조건

후처리

1. 1
   농축the reaction was concentrated
2. 2
   workup.ADDITIONthe residue was diluted with H2O
3. 3
   여과the resultant solid was filtered
4. 4
   세척washed with petroleum ether

실험 절차

To Intermediate 5C (5 g, 17.7 mmol) in MeOH (50 mL) and THF (25 mL) was added 10% NaOH solution (25 mL). After 2 h, the reaction was concentrated and the residue was diluted with H2O. The pH was adjusted to 2 to 3 with 1.5N HCl and the resultant solid was filtered and washed with petroleum ether to afford 2 g of Intermediate 5. MS (ESI) m/z: 269.0 (M+H)+.

출처