반응 #92065

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p-nitrobenzaldehyde

compound 3

methyl 1-amino-5-carbamoyl-1H-pyrrole-3-carboxylate

→

methyl 2-p-nitrophenyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-formate

수율 72.0%

반응 조건

후처리

1. 1
   기타According to the general preparation method
2. 2
   기타to give compound Ma as light yellow solid in 72.0% yield

실험 절차

According to the general preparation method described in example 5 above, p-nitrobenzaldehyde reacts with compound 3 to give compound Ma as light yellow solid in 72.0% yield. m.p.>300° C. 1H NMR (300 MHz, DMSO-d6): δ 12.52 (s, 1H), 8.38 (d, J=8.5 Hz, 2H), 8.22 (s, 1H), 8.21 (d, J=8.5 Hz, 2H), 7.26 (s, 1H), 3.80 (s, 3H). LRMS (EI) m/z (%): 314 (M+, 85), 283 (100). HRMS calcd. C14H10N4O5: 314.0651. found: 314.0659.

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