반응 #92014

ord-c5c302b899a1446096a3d6e6e90b136e

반응 방정식

CCCOC(=O)[C@H](Cc1ccc(-c2c(C)n(C)c(=O)n(C)c2=O)cc1)NC(=O)C1(CCCCN=[N+]=[N-])CCCC1
(S)-2-[[1-(4-azidobutyl)cyclopentanecarbonyl]amino]-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid propyl ester
[Na+].[OH-]
NaOH
→
Cc1c(-c2ccc(C[C@H](NC(=O)C3(CCCCN=[N+]=[N-])CCCC3)C(=O)O)cc2)c(=O)n(C)c(=O)n1C
title compound
Cc1c(-c2ccc(C[C@H](NC(=O)C3(CCCCN=[N+]=[N-])CCCC3)C(=O)O)cc2)c(=O)n(C)c(=O)n1C
(S)-2-[[1-(4-azidobutyl)cyclopentanecarbonyl]amino]-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid

반응물

CCCOC(=O)[C@H](Cc1ccc(-c2c(C)n(C)c(=O)n(C)c2=O)cc1)NC(=O)C1(CCCCN=[N+]=[N-])CCCC1
(S)-2-[[1-(4-azidobutyl)cyclopentanecarbonyl]amino]-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid propyl ester
[Na+].[OH-]
NaOH

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound was prepared using a similar procedure as described in Example 1, Step 9, starting from (S)-2-[[1-(4-azidobutyl)cyclopentanecarbonyl]amino]-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid propyl ester (4.1 g, 7.42 mmol) and NaOH (35 mL, 35 mmol, 1M) which resulted in a white solid (3.75 g, 99%). ES(+)-HRMS m/e calcd. for C26H34N6O5 (M+H)+ 511.2664, obsd. 511.2664.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09447035B2uspto-grants-2016_09