반응 #91990

반응 방정식

1,2-dibromoethane

diisopropylamine

n-butyl lithium

cyclopentanecarboxylic acid methyl ester

ammonium chloride

→

1-[2-bromoethyl]cyclopentanecarboxylic acid methyl ester

수율 80.2%

용매

THF

—

hexanes

THF

반응 조건

후처리

1. 1
   온도while maintaining the temperature below 0° C
2. 2
   workup.ADDITIONAfter addition
3. 3
   온도maintaining the internal temperature between −60 to −70° C
4. 4
   workup.ADDITIONAfter addition
5. 5
   workup.STIRRINGthe reaction mixture was stirred for 1 h at −50 to −60° C
6. 6
   workup.STIRRINGthe light brown suspension was stirred for 1 h at −70 to −60° C
7. 7
   온도to warm to room temperature
8. 8
   workup.STIRRINGstirred overnight
9. 9
   추출the organic compound was extracted into ether (2×100 mL)
10. 10
    세척The combined extracts were washed with a saturated solution of sodium chloride (150 mL)
11. 11
    건조dried over anhydrous magnesium sulfate
12. 12
    여과After filtration of the drying agent
13. 13
    농축the solution was concentrated under vacuum
14. 14
    workup.DISTILLATIONthe resulting residue was distilled at 95-105° C./2.5 mm Hg

실험 절차

To a solution of diisopropylamine (56 mL, 396 mmol) in TI-IF (85 mL) was added dropwise a solution of n-butyl lithium (240 mL, 393 mmol, 1.6M) in hexanes at −10° C. while maintaining the temperature below 0° C. After addition, the solution was stirred for 30 min at 0° C. To this, a solution of cyclopentanecarboxylic acid methyl ester (37.4 g, 263 mmol) in THF (50 mL) was added dropwise at −70° C. maintaining the internal temperature between −60 to −70° C. After addition, the reaction mixture was stirred for 1 h at −50 to −60° C. Then, a solution of 1,2-dibromoethane (47 mL, 545 mmol) in THF (50 mL) was added dropwise and the light brown suspension was stirred for 1 h at −70 to −60° C. Then, it was allowed to warm to room temperature and stirred overnight. The reaction mixture was poured into a saturated aqueous solution of ammonium chloride (200 mL) and the organic compound was extracted into ether (2×100 mL). The combined extracts were washed with a saturated solution of sodium chloride (150 mL) and dried over anhydrous magnesium sulfate. After filtration of the drying agent, the solution was concentrated under vacuum and the resulting residue was distilled at 95-105° C./2.5 mm Hg to obtain 49.6 g (80% yield) of 1-[2-bromoethyl]cyclopentanecarboxylic acid methyl ester as a colorless oil.

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