반응 #9191

반응 방정식

ethyl-2-amino-thiazole-5-carboxylate

di-t-butyldicarbonate

tetrahydrofuran

→

title compound

수율 70.0%

Ethyl-2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylate

수율 70.0%

반응 조건

후처리

1. 1
   기타The solvent was evaporated in vacuo
2. 2
   세척The solid was washed with ether (10 mL, 3×)
3. 3
   기타dried in vacuo

실험 절차

A suspension of ethyl-2-amino-thiazole-5-carboxylate (972 mg, 6 mmol, B. Plouvler, C. Bailly, R. Houssin, j-P. Henlchart Heterocyles 32(4), 693–701, 1991 and H. J. Becker, J. de Jonge Rec. Trav. Chim, 61, 463, 1942), di-t-butyldicarbonate (1.94 g, 9 mmol) and 4-dimethylaminopyridine (73 mg, 0.6 mmol) in dry tetrahydrofuran (75 mL) was stirred under nitrogen for 24 h. The solvent was evaporated in vacuo. The residue was suspended in ether (50 mL). The solid was washed with ether (10 mL, 3×), and dried in vacuo to obtain the title compound (1.1 g, 70%).

출처