반응 #91671

반응 방정식

2-bromopyridin-3-ol

pyrrolidine

HCl

→

2-(pyrrolidin-1-yl)pyridin-3-ol

수율 41.3%

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate and dichloromethane
2. 2
   건조The obtained organic layer was dried over magnesium sulfate
3. 3
   농축concentrated under reduced pressure
4. 4
   기타The concentrate was purified by column chromatography

실험 절차

2-bromopyridin-3-ol (200 mg, 1.15 mmol) and pyrrolidine (184 mg, 2.58 mmol) were added in a reaction tube, followed by reacting in microwave at 120° C. for 20 minutes. The reaction mixture was added with 1 M HCl solution to neutralized, and extracted with ethyl acetate and dichloromethane. The obtained organic layer was dried over magnesium sulfate, and concentrated under reduced pressure. The concentrate was purified by column chromatography to obtain 2-(pyrrolidin-1-yl)pyridin-3-ol (78 mg, 41%).

출처