반응 #91667

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4-fluoro-2-(furan-3-yl)-6-methylphenol

Compound 6-11

4-fluoro-2-(furan-3-yl)-6-methylphenol

→

4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenol

수율 76.5%

용매

methanol

반응 조건

후처리

1. 1
   기타After the completion of the reaction
2. 2
   여과the reaction mixture was filtered through Celite
3. 3
   농축The filtrate was concentrated under reduced pressure
4. 4
   기타The concentrate was purified by column chromatography (silica gel; hexane/ethyl acetate, 9/1)

실험 절차

4-fluoro-2-(furan-3-yl)-6-methylphenol (Compound 6-11) (471 mg, 2.45 mmol) were dissolved in methanol. Palladium carbon (64.3 mg, 5 wt %) was added thereto, followed by stirring under hydrogen balloon for 24 hours. After the completion of the reaction, the reaction mixture was filtered through Celite. The filtrate was concentrated under reduced pressure. The concentrate was purified by column chromatography (silica gel; hexane/ethyl acetate, 9/1) to obtain 4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenol (368 mg, 76%) as a white solid.

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