반응 #91662

반응 방정식

sodium carbonate

3-Bromophenol

pyridin-3-ylboronic acid

→

3-(pyridin-3-yl)phenol

수율 78.8%

용매

dimethoxyethane water

반응 조건

후처리

1. 1
   기타After the completion of the reaction
2. 2
   여과the reaction mixture was filtered
3. 3
   workup.ADDITIONThe filtrate was added with water
4. 4
   추출extracted with ethyl acetate
5. 5
   건조The obtained organic layer was dried over magnesium sulfate
6. 6
   기타purified by column chromatography (hexane:ethyl acetate=9:1)

실험 절차

3-Bromophenol (500 mg, 2.86 mmol) and pyridin-3-ylboronic acid (422 mg, 3.76 mmol) were dissolved in dimethoxyethane/water=5 mL/2.5 mL. Pd(dppf)Cl2 (118 mg, 0.14 mmol) and sodium carbonate (919 mg, 8.67 mmol) were added thereto, followed by stirring in microwave at 120° C. for 20 minutes. After the completion of the reaction, the reaction mixture was filtered using Celite. The filtrate was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, and purified by column chromatography (hexane:ethyl acetate=9:1) to obtain 3-(pyridin-3-yl)phenol (386 mg, 78%).

출처