반응 #91660

반응 방정식

2-Bromo-4-methoxyphenol

2-furanylboronic acid

sodium carbonate

water

→

2-(furan-2-yl)-4-methoxyphenol

수율 57.0%

용매

DME

반응 조건

후처리

1. 1
   기타After the completion of the reaction
2. 2
   여과the reaction mixture was filtered
3. 3
   workup.ADDITIONThe filtrate was added with water
4. 4
   추출extracted with ethyl acetate
5. 5
   건조The obtained organic layer was dried over magnesium sulfate
6. 6
   기타purified by column chromatography (hexane:ethyl acetate=9:1)

실험 절차

2-Bromo-4-methoxyphenol (400 mg, 1.97 mmol), 2-furanylboronic acid (287 mg, 2.56 mmol), Pd(dppf)Cl2 (81 mg, 0.1 mmol) and sodium carbonate (626 mg, 5.91 mmol) were dissolved in DME:water=4 mL:2 mL, followed by stirring in microwave at 120° C. for 20 minutes. After the completion of the reaction, the reaction mixture was filtered using Celite. The filtrate was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, and purified by column chromatography (hexane:ethyl acetate=9:1) to obtain 2-(furan-2-yl)-4-methoxyphenol (212 mg, 57%).

출처