반응 #91656

반응 방정식

2-Bromopyridin-3-ol

3-furan boronic acid

sodium carbonate

→

2-(furan-3-yl)pyridin-3-ol

수율 27.0%

용매

dimethoxyethane water

반응 조건

후처리

1. 1
   기타After the completion of the reaction
2. 2
   여과the reaction mixture was filtered
3. 3
   workup.ADDITIONThe filtrate was added with water
4. 4
   추출extracted with ethyl acetate
5. 5
   건조The obtained organic layer was dried over magnesium sulfate
6. 6
   기타purified by column chromatography (ethyl acetate:hexane=1:3)

실험 절차

2-Bromopyridin-3-ol (200 mg, 1.15 mmol), 3-furan boronic acid (574 mg, 1.38 mmol), sodium carbonate (365 mg, 12.8 mmol) and Pd2(dppf)2Cl2 (187 mg, 0.23 mmol) were dissolved in dimethoxyethane/water 2 mL/1 mL, followed by stirring in microwave at 120° C. for 20 minutes. After the completion of the reaction, the reaction mixture was filtered using Celite. The filtrate was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, and purified by column chromatography (ethyl acetate:hexane=1:3) to obtain 2-(furan-3-yl)pyridin-3-ol (50 mg, 27%).

출처