반응 #91651

반응 방정식

4-Bromo-2,6-dimethylphenol

3-furanylboronic acid

sodium carbonate

water

→

4-(furan-3-yl)-2,6-dimethylphenol

수율 68.7%

용매

DME

반응 조건

후처리

1. 1
   기타After the completion of the reaction
2. 2
   여과the reaction mixture was filtered
3. 3
   추출The obtained filtrate was extracted with ethyl acetate
4. 4
   건조dried over magnesium sulfate
5. 5
   기타purified by column chromatography (hexane:ethyl acetate=9:1)

실험 절차

4-Bromo-2,6-dimethylphenol (350 mg, 1.74 mmol), 3-furanylboronic acid (269 mg, 2.26 mmol), Pd(dppf)Cl2 (71 mg, 0.087 mmol) and sodium carbonate (553 mg, 5.22 mmol) were dissolved in DME:water=4 mL:2 mL, followed by stirring in microwave at 120° C. for 20 minutes. After the completion of the reaction, the reaction mixture was filtered using Celite. The obtained filtrate was extracted with ethyl acetate, dried over magnesium sulfate, and purified by column chromatography (hexane:ethyl acetate=9:1) to obtain 4-(furan-3-yl)-2,6-dimethylphenol (225 mg, 50%).

출처