반응 #91648

반응 방정식

sodium hydrogen carbonate

Furan-3-ylboronic acid

sodium carbonate

2-Bromo-4,6-dimethylphenol

→

2-(furan-3-yl)-4,6-dimethylphenol

수율 54.0%

용매

dimethoxyethane water

반응 조건

후처리

1. 1
   온도under reflux
2. 2
   기타After the completion of the reaction
3. 3
   추출extracted with ethyl acetate
4. 4
   건조The obtained organic layer was dried over magnesium sulfate
5. 5
   농축concentrated under reduced pressure
6. 6
   기타purified by column chromatography

실험 절차

2-Bromo-4,6-dimethylphenol (1.8 g, 8.9 mmol) was dissolved in dimethoxyethane/water (2:1). Furan-3-ylboronic acid (1 g, 8.9 mmol), Pd(dppf)Cl2 (0.36 g, 0.45 mmol) and sodium carbonate (3.7 g, 45 mmol) were added thereto, followed by stirring for 1 hour under reflux. After the completion of the reaction, the reaction mixture was added with a saturated sodium hydrogen carbonate aqueous solution, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, concentrated under reduced pressure, and purified by column chromatography to obtain 2-(furan-3-yl)-4,6-dimethylphenol (0.9 g, 54%).

출처