반응 #91441

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N4-cyclopentyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine

(4,5-difluoro-2-methylphenyl)amine

→

titled compound

N4-(4,5-difluoro-2-methylphenyl)-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine

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후처리

1. 1
   기타The titled compound was synthesized
2. 2
   기타The crude material was purified by column chromatography
3. 3
   세척eluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1)
4. 4
   세척the final product was washed with diethyl ether

실험 절차

The titled compound was synthesized according to the procedure described for preparation of N4-cyclopentyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine (Example 29) using (4,5-difluoro-2-methylphenyl)amine instead of cyclopentanamine. The crude material was purified by column chromatography eluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1), and then the final product was washed with diethyl ether to afford the titled compound as a white solid. 1H NMR (300 MHz, DMSO-d6) δ ppm 2.02 (s, 3H), 2.06 (s, 3H), 2.16 (s, 3H), 4.34 (bs, 2H), 6.81 (bs, 1H), 7.07-7.41 (m, 4H), 7.56 (bs, 1H), 7.63 (d, J=7.3 Hz, 1H), 8.42 (d, J=4.2 Hz, 1H); MS (ESI) m/z 356.6 (M+1)+.

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