반응 #91325

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3,4-dichlorobenzylamine

3-fluoroisonicotinic acid

→

title compound

수율 37.0%

3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylic acid

수율 37.0%

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실험 절차

The title compound was prepared in 37% yield from 3,4-dichlorobenzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.48 (br s, 1H), 8.10 (s, 1H), 7.84 (d, 1H, J=5.0 Hz), 7.57-7.65 (m, 3H), 7.35 (dd, 1H, J=8.3, 1.9 Hz), 4.59 (s, 2H). [M+H] calc'd for C13H10Cl2N2O2, 297, 299. found 297, 299.

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