반응 #91172

반응 방정식

Sulfuric acid

ethyl 4-chloroacetoacetate

2,4-difluororesorcinol

→

title compound

수율 24.0%

4-chloromethyl-6,8-difluoro-7-hydroxy-2-chromenone

수율 24.0%

용매

반응 조건

후처리

1. 1
   여과The precipitate was filtered
2. 2
   세척washed with water
3. 3
   기타dried by nitrogen gas

실험 절차

Sulfuric acid (2 mL) in a flask was cooled to 0° C. After ethyl 4-chloroacetoacetate (0.62 g, 3.8 mmol) was added thereto, 2,4-difluororesorcinol (0.5 g, 3.4 mmol) was added dropwise thereto. The mixture was stirred at room temperature for 2 hours, and the reactant was placed in ice water. The precipitate was filtered, washed with water, and dried by nitrogen gas to obtain the title compound (0.2 g, 24%).

출처