반응 #91161

반응 방정식

6-mercapto-pyridine-2-carboxylic acid ethyl ester

Cs2CO3

bromo cyclobutane

→

title compound

수율 93.0%

6-cyclobutylsulfanyl-pyridine-2-carboxylic acid ethyl ester

수율 93.0%

용매

CH3CN

반응 조건

후처리

1. 1
   기타After the termination of the reaction
2. 2
   여과the reactant was filtered
3. 3
   농축concentrated under reduced pressure
4. 4
   기타purified by column chromatography (eluent, EtOAc/Hex=1/5)

실험 절차

After 6-mercapto-pyridine-2-carboxylic acid ethyl ester (0.40 g, 2.18 mmol) was dissolved in CH3CN (9 mL), Cs2CO3(2.667 g, 6.54 mmol) and bromo cyclobutane (0.385 mL, 3.27 mmol) were added thereto, and the mixture was stirred at 50° C. for 18 hours. After the termination of the reaction, the reactant was filtered, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (0.481 g, 92%).

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