반응 #91136

반응 방정식

6-Bromo-pyridine-2-carboxylic acid methyl ester

Cs2CO3

2-propanethiol

→

title compound

수율 89.2%

6-isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester

수율 89.2%

용매

DMF

반응 조건

후처리

1. 1
   기타After the termination of the reaction
2. 2
   여과the reactant was filtered
3. 3
   농축concentrated under reduced pressure

실험 절차

6-Bromo-pyridine-2-carboxylic acid methyl ester (0.15 g, 0.69 mmol) was added with DMF (2.3 mL), Cs2CO3(0.45 g, 1.38 mmol) and 2-propanethiol (0.064 mL, 0.69 mmol) in turn, and the mixture was stirred at room temperature for 18 hours. After the termination of the reaction, the reactant was filtered and concentrated under reduced pressure to obtain the title compound (0.13 g, 88%).

출처