반응 #90556
ord-52254e9e48e4418b87446d687f3fac69
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1세척washed with water (3×25 mL)
- 2건조The organic layer was dried over sodium sulphate
- 3농축concentrated
- 4기타to get the crude, which
- 5기타was purified through flash chromatography
- 6세척The compound 242 was eluted at 30% ethyl acetate in hexane
실험 절차
To a solution of 13 (0.1 g, 0.404 mmol) in MeOH/H2O (1:1) was added nicotinaldehyde 241 (0.052 g, 0.484 mmol) and NaOH (0.032 g, 0.808 mmol). The reaction was stirred at RT for 6 h, diluted with chloroform and washed with water (3×25 mL). The organic layer was dried over sodium sulphate and concentrated to get the crude, which was purified through flash chromatography by using 100-200 mesh silica gel. The compound 242 was eluted at 30% ethyl acetate in hexane to afford yellow coloured solid (E)-6-methoxy-5-morpholino-2-(pyridin-3-ylmethylene)-2,3-dihydro-1H-inden-1-one 242.