반응 #90412

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DCM EtOAc

VII

(E)-N′-(2,7-dicyanobenzo[d]thiazol-6-yl)-N,N-dimethylformimidamide

4-tert-butylaniline

KBr

→

9-(4-tert-Butylbenzylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

수율 99.0%

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실험 절차

Prepared from VII and 4-tert-butylaniline. Flash chromatography eluent (DCM-EtOAc, 7:3). Yield: 99%; yellow solid; mp 154° C.; IR (KBr) νmax/cm−1 2958, 2235, 1693, 1649, 1582, 1505, 1466, 1408, 1349, 1288, 1219, 1155, 1125, 989, 968, 894, 831; 1H NMR (300 MHz, DMSO-d6) δ 8.49 (d, 1H, J=9.0 Hz), 8.07 (s, 1H), 7.76 (d, 1H, J=9.0 Hz), 7.40 (d, 2H, J=7.8 Hz), 7.12 (m, 2H), 1.31 (s, 9H); HRMS calcd for C20H18N5S (M+H+): 360.1283, found 360.1273.

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