반응 #90303

반응 방정식

quinolin-4-ol

Nitric acid

→

3-nitro-quinoline-4-ol

용매

ethanol

propionic acid

ethanol

반응 조건

후처리

1. 1
   온도while maintaining the reaction mixture temperature at 125° C
2. 2
   기타Reaction
3. 3
   workup.STIRRINGwas stirred at 125° C. for 15 min.
4. 4
   온도cooled to ambient temperature
5. 5
   여과was collected by vacuum filtration
6. 6
   세척Solid was washed successively with ethanol, water and ethanol
7. 7
   기타Resulting yellow solid
8. 8
   온도was heated
9. 9
   여과filtered from hot mixture

실험 절차

A mixture of quinolin-4-ol (1 eq.) in propionic acid was heated to 125° C. with stirring. Nitric acid (2.2 eq.) was added drop wise to the stirred solution while maintaining the reaction mixture temperature at 125° C. Reaction was stirred at 125° C. for 15 min. and cooled to ambient temperature. The reaction was diluted with ethanol and solid was collected by vacuum filtration. Solid was washed successively with ethanol, water and ethanol. Resulting yellow solid was heated in refluxing ethanol and filtered from hot mixture to give pure 3-nitro-quinoline-4-ol.

출처