반응 #90289

반응 방정식

2-(trifluoromethyl)pyridine-3-carbothioamide

1-[3,4-bis(benzyloxy)-5-nitrophenyl]-2-bromoethanone

→

4-(3,4-bis(benzyloxy)-5-nitrophenyl)-2-(2-(trifluoromethyl)pyridin-3-yl)thiazole

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONthe reaction mixture was poured onto water (50 mL)
2. 2
   여과The resulting precipitate was filtered off
3. 3
   세척washed with water (25 mL)
4. 4
   기타dried
5. 5
   기타Recrystallisation from dichloromethane/isopropanol

실험 절차

A mixture of 2-(trifluoromethyl)pyridine-3-carbothioamide (0.227 g, 1.10 mmol) and 1-[3,4-bis(benzyloxy)-5-nitrophenyl]-2-bromoethanone (0.50 g, 1.10 mmol) were refluxed overnight in absolute ethanol (5 mL). After cooling to room temperature, the reaction mixture was poured onto water (50 mL). The resulting precipitate was filtered off, washed with water (25 mL) and dried. Recrystallisation from dichloromethane/isopropanol afforded 4-(3,4-bis(benzyloxy)-5-nitrophenyl)-2-(2-(trifluoromethyl)pyridin-3-yl)thiazole, 0.539 g (87%).

출처